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Key Common Genes with LTF and MMP9 Between Sepsis and Relapsed B-Cell Lineage Acute Lymphoblastic Leukemia in
Ying-Ping Xiao1, Yu-Cai Cheng1, Chun Chen1
1Pediatric Hematology Laboratory, Division of Hematology/Oncology, Department of Pediatrics, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China.
Biomedicines
|September 27, 2025
Summary
Pediatric sepsis and relapsed B-cell acute lymphoblastic leukemia share key genes, lactotransferrin (LTF) and matrix metallopeptidase 9 (MMP9). These findings offer new diagnostic and therapeutic strategies for these critical childhood diseases.
Area of Science:
- Genetics and Molecular Biology
- Pediatric Oncology
- Infectious Diseases
Background:
- Pediatric sepsis is a severe condition linked to acute lymphoblastic leukemia (ALL) progression and B-cell ALL (B-ALL) relapse.
- Limited research exists on shared genetic factors between pediatric sepsis and relapsed B-ALL.
Purpose of the Study:
- To identify novel common genetic factors and molecular pathways between pediatric sepsis and relapsed B-ALL.
- To explore potential diagnostic biomarkers and therapeutic targets for these conditions.
Main Methods:
- Retrospective analysis of gene expression datasets for pediatric sepsis and relapsed B-ALL from the Gene Expression Omnibus database.
- Identification of differentially expressed genes, construction of protein-protein interaction networks, and application of machine learning models.
- Functional enrichment analysis, transcription factor-mRNA-microRNA network construction, and molecular docking for drug prediction.
Main Results:
- Two shared diagnostic genetic markers, lactotransferrin (LTF) and matrix metallopeptidase 9 (MMP9), were identified and found to be upregulated in both conditions.
- Specificity protein 1 (SP1) was identified as a key transcription factor regulating LTF and MMP9.
- Molecular docking suggested potential therapeutic roles for curcumin with MMP9 and reserpine with LTF.
Conclusions:
- LTF and MMP9 play significant roles in the molecular pathogenesis of pediatric sepsis and relapsed B-ALL.
- These findings provide novel insights for improving clinical diagnosis and developing targeted therapies.
