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Sleep Disorders in Children with Autism Spectrum Disorder: Developmental Impact and Intervention Strategies

Maria Ludovica Albertini1, Giulia Spoto2, Graziana Ceraolo1

  • 1Unit of Child Neurology and Psychiatry, Department of Human Pathology of the Adult and Developmental Age "Gaetano Barresi", University of Messina, 98125 Messina, Italy.

Brain Sciences
|September 27, 2025
PubMed

Insights

Sleep disorders are common in children with Autism Spectrum Disorder (ASD), affecting neurodevelopment. Addressing these sleep issues is key for early diagnosis and improving quality of life.

Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Pediatrics

Background:

  • Sleep disorders are highly prevalent in children with Autism Spectrum Disorder (ASD).
  • Sleep disturbances in ASD impact neurodevelopment, daily functioning, and sensory processing.
  • Disrupted sleep negatively affects synaptic plasticity and neurological development in children.

Purpose of the Study:

  • To explore the link between sleep disorders and Autism Spectrum Disorder (ASD).
  • To understand the neurobiological mechanisms underlying sleep disturbances in ASD.
  • To identify potential early diagnostic indicators and therapeutic targets for ASD-related sleep issues.

Main Methods:

  • Review of existing literature on sleep disorders in ASD.
  • Analysis of neurobiological underpinnings of sleep alterations in ASD.
  • Examination of sensory processing differences and their impact on sleep.

Main Results:

  • Sleep architecture alterations and regulatory issues are common in ASD.
  • Sensory processing differences in ASD can worsen sleep disturbances.
  • Sleep problems in ASD can influence cognitive and behavioral outcomes.

Conclusions:

  • Sleep alterations may serve as early indicators for ASD diagnosis and intervention.
  • Understanding the neurobiology of sleep in ASD is crucial for targeted therapies.
  • Multidisciplinary approaches involving pharmacological, nutraceutical, and behavioral interventions are vital for improving outcomes in children with ASD.

Keywords:
EEGautismcircadian rhythmsdevelopmentmelatoninsensory processingsleep disorders

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