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Accelerated Optimized Protocol of Intermittent Theta-Burst Stimulation for Negative Symptoms in Schizophrenia
Ivan Taiar1, July Silveira Gomes1, Lucas Jorge1
1Interdisciplinary Laboratory of Clinical Neurosciences (LINC), Department of Psychiatry, Paulista School of Medicine, Federal University of São Paulo (EPM/UNIFESP), São Paulo 04017-030, Brazil.
Brain Sciences
|September 27, 2025
Summary
This study investigated an accelerated intermittent theta burst stimulation (iTBS) protocol for schizophrenia negative symptoms (NSs). Results suggest iTBS may effectively reduce NSs, offering a promising therapeutic avenue.
Area of Science:
- Neuroscience
- Psychiatry
- Clinical Trials
Background:
- Intermittent theta burst stimulation (iTBS) shows potential for improving negative symptoms (NSs) in schizophrenia.
- Optimizing iTBS protocols for shorter durations is crucial for clinical application.
- Understanding iTBS effects on sleep and autonomic regulation is key to its therapeutic mechanisms.
Purpose of the Study:
- To evaluate the efficacy of an accelerated iTBS protocol in reducing NSs in schizophrenia patients.
- To assess the impact of accelerated iTBS on sleep patterns, symptom severity, and cognition.
- To hypothesize a 20% reduction in Brief Negative Symptom Scale (BNSS) scores with active iTBS.
Main Methods:
- A double-blind, randomized, sham-controlled trial involving 60 schizophrenia participants.
- An accelerated iTBS protocol: four daily sessions, 600 pulses/session for five days.
- Assessment of clinical symptoms, cognition, and heart rate variability at baseline, post-intervention, and 30-day follow-up.
Main Results:
- The accelerated iTBS protocol demonstrated promising effects on negative symptoms.
- Further research is needed to establish optimal high-dosage protocols.
- The study provides data on clinical applicability and physiological effects of neuromodulation.
Conclusions:
- Accelerated iTBS shows potential for treating negative symptoms in schizophrenia.
- This research contributes to optimizing therapeutic strategies for schizophrenia.
- The study enhances understanding of neuromodulation's physiological underpinnings.
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