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Related Concept Videos

Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Cultivate Primary Nasal Epithelial Cells from Children and Reprogram into Induced Pluripotent Stem Cells
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Structural and Functional Studies on Key Epigenetic Regulators in Asthma.

Muhammad Fakhar1,2, Mehreen Gul1,2, Wenjin Li2

  • 1College of Civil and Transportation Engineering, Shenzhen University, Shenzhen 518060, China.

Biomolecules
|September 27, 2025
PubMed
Summary
This summary is machine-generated.

Epigenetic regulators, including DNA, histone, and RNA modifiers, are crucial in asthma development. Understanding these "writers," "erasers," and "readers" offers new targets for asthma therapies.

Keywords:
DNMT1DNMT3AIGF2BP2SIRT familyYTHDF1/2asthmaepigenetic regulationp300/CBPprecision medicine

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Area of Science:

  • Molecular Biology
  • Immunology
  • Genetics

Background:

  • Asthma is a complex chronic airway disease with genetic and environmental influences.
  • Epigenetic regulation plays a significant role in asthma's pathogenesis and diverse clinical presentations.
  • Epigenetic mechanisms, including DNA methylation, histone modifications, and RNA modifications, are key to understanding asthma.

Purpose of the Study:

  • To review the critical epigenetic regulators (writers, erasers, readers) involved in asthma.
  • To explore the structural and functional dynamics of these epigenetic modifiers in airway inflammation and remodeling.
  • To provide a framework for developing epigenetic biomarkers and targeted therapies for asthma.

Main Methods:

  • Review of literature on epigenetic regulators in asthma.
  • Analysis of structural and functional dynamics of key proteins like p300/CBP, SIRT family, DNMTs, TET1, MBD2, and the m6A machinery (METTL3, FTO, YTHDFs).
  • Examination of conserved catalytic domains and interaction motifs for mechanistic insights.

Main Results:

  • Epigenetic regulators significantly influence gene expression, immune responses, and airway remodeling in asthma.
  • Specific proteins like histone acetyltransferases, deacetylases, DNA methyltransferases, demethylases, methyl-CpG-binding proteins, and m6A RNA modifiers are implicated.
  • Structural characterizations reveal conserved domains critical for epigenetic functions in asthma.

Conclusions:

  • Epigenetic pathways are central to asthma pathogenesis and heterogeneity.
  • Understanding these epigenetic mechanisms can lead to novel therapeutic strategies and biomarkers for asthma.
  • Future research should focus on phenotype-specific epigenomic profiling and structure-guided drug design for precision asthma management.