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Updated: Jan 16, 2026

Fabrication of Amyloid-β-Secreting Alginate Microbeads for Use in Modelling Alzheimer's Disease
Published on: July 6, 2019
Translating Alzheimer's Disease Mechanisms into Therapeutic Opportunities
Jiejia Li1,2,3,4,5, Liyun Wang1, Xiaodan Zhang1
1School of Pharmacy, Nantong University, No. 9, Seyuan Road, Nantong 226001, China.
None:
Alzheimer's disease (AD), characterized by progressive cognitive decline and functional impairment, is the most prevalent cause of dementia, and it poses a significant socioeconomic and caregiving burden on patients, families, and healthcare systems. Notwithstanding comprehensive research, the precise causes underlying AD remain ambiguous. Evidence increasingly indicates that AD is a multifactorial and heterogeneous disease involving a mix of genetic and environmental factors. The amyloid-cascade hypothesis, neuroinflammation and immunity, vascular pathology, and oxidative stress all fulfill significant functions in the onset and development of AD. This review primarily examines the critical pathogenesis, key biomarkers, and novel therapeutic strategies of Alzheimer's disease to inform future research directions.
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