Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Intestinal oxalate absorption. I. Absorption in vitro.

Research in Experimental Medicine. Zeitschrift Fur Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie

|August 16, 1977

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Der Internist·2017

Same author

13C-methacetin-breath test compared to also noninvasive biochemical blood tests in predicting hepatic fibrosis and cirrhosis in chronic hepatitis C.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2008

Same author

13C-breath tests: current state of the art and future directions.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2007

Same author

The folic acid metabolite L-5-methyltetrahydrofolate effectively reduces total serum homocysteine level in orthotopic liver transplant recipients: a double-blind placebo-controlled study.

European journal of clinical nutrition·2007

Same author

Polymorphisms in the methylenetetrahydrofolate reductase gene are determinant for vascular complications after liver transplantation.

European journal of clinical nutrition·2007

Same author

Predictors of reduced health-related quality of life in adults with coeliac disease.

Alimentary pharmacology & therapeutics·2007

Intestinal oxalate absorption, a cause of enteric hyperoxaluria after ileal resection, occurs via passive diffusion. Bile acids enhance this absorption, while calcium reduces it, suggesting cholestyramine

Area of Science:

Gastroenterology
Nephrology
Urology

Background:

Enteric hyperoxaluria and oxalate urolithiasis in patients with ileal resection are linked to intestinal oxalate hyperabsorption.
The precise mechanism driving this oxalate hyperabsorption remains unclear.

Purpose of the Study:

To investigate the intestinal transport mechanism of oxalic acid in rats.
To elucidate the roles of bile acids, calcium, and cholestyramine in oxalate absorption.

Main Methods:

Utilized an in vitro technique to examine oxalic acid transport across rat intestinal segments.
Assessed the impact of bile acids, calcium, and cholestyramine on oxalic acid absorption.

Main Results:

Oxalic acid absorption occurs via simple passive diffusion, with absorption rates decreasing from colon to duodenum.

Related Experiment Videos

Bile acids significantly enhance oxalic acid absorption, whereas calcium markedly reduces it.

Cholestyramine did not directly affect oxalic acid absorption but reduced bile acid-enhanced absorption.

Conclusions:

The study identifies passive diffusion as the primary mechanism for intestinal oxalate absorption.
Bile acid binding activity, not direct oxalate binding, likely mediates cholestyramine's therapeutic effect in hyperoxaluria.