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Updated: Jan 16, 2026
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Published on: April 13, 2021
N-Terminal Pro-B-Type Natriuretic Peptide and Cardiac Troponin T in Stable Renal Transplant Recipients and All-Cause
Zbigniew Heleniak1, Marcel G Naik2, Georgios Eleftheriadis2
1Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, 80-210 Gdańsk, Poland.
Introduction:
In renal transplant recipients (RTRs), kidney graft failure and cardiovascular (CV) disease are prevalent and associated with mortality.
Objectives:
The objective of the study was to evaluate biomarkers, (cardiac troponin T (cTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP)), to identify RTRs who are at greater risk of death, CV event, and graft renal survival.
Patients And Methods:
A total of 342 stable RTRs were enrolled in this study, with a median follow-up time of 54 months. The probability of death, CV event, and renal graft survival were calculated using Kaplan-Meier analysis for the group defined by cTnT and NT-proBNP levels above the cutoff values.
Results:
The probability of death for troponin T level above the cut-off was 23% and for NT-proBNP 29%. For CV events the probability for troponin T was 20% and for NT-proBNP it was 21%. Troponin T concentrations above the cutoff point suggested a 25% probability of death-censored graft survival. For NT-proBNP, it was 26%. The probability of overall graft survival was 38% for patients with higher troponin T levels, and 40% for NT proBNP.
Conclusions:
These data suggest that cTnT and NT-proBNP could potentially identify patients at high risk for death, CV event, and graft survival.
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