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A Comprehensive Oncological Biomarker Framework Guiding Precision Medicine.

Reza Bayat Mokhtari1,2,3, Manpreet Sambi3, Faezeh Shekari3

  • 1Department of Pharmacology and Therapeutics, Roswell Park Comprehensive Cancer Center, 265 Elm and Carlton Streets, Buffalo, NY 14263, USA.

Biomolecules
|September 27, 2025
PubMed
Summary
This summary is machine-generated.

A new Comprehensive Oncological Biomarker Framework integrates diverse data for personalized cancer treatment. This approach aims to overcome immunotherapy limitations and improve patient outcomes in precision oncology.

Keywords:
biomarkerscancer immunotherapycomprehensive oncological biomarker frameworkgut microbiomeprecision medicinetumor microenvironment

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Area of Science:

  • Oncology
  • Immunotherapy
  • Biomarker Discovery

Background:

  • Cancer immunotherapy shows promise but faces challenges like tumor heterogeneity and resistance.
  • Lack of predictive biomarkers hinders effective treatment selection and toxicity management.
  • Liquid biopsy and microbiome profiling are emerging tools for precision cancer care.

Purpose of the Study:

  • To introduce a Comprehensive Oncological Biomarker Framework (COBF).
  • To integrate multi-modal data for personalized cancer management.
  • To address limitations in current immunotherapy strategies.

Main Methods:

  • Integrating genetic, molecular, imaging, histopathology, multi-omics, and liquid biopsy data.
  • Generating a patient-specific molecular fingerprint.
  • Incorporating microbiome signatures and clinical/social factors.

Main Results:

  • The framework supports individualized diagnosis, prognosis, and treatment selection.
  • It enables precise monitoring of therapeutic response.
  • Emerging biomarkers refine patient stratification for optimized therapy.

Conclusions:

  • The COBF addresses tumor heterogeneity and immune evasion.
  • It enhances precision oncology by uniting molecular insights with clinical factors.
  • This holistic approach aims to improve patient outcomes in cancer care.