Nevus with Intralymphatic Nevus Cell Protrusion and Lymphatic Invasion

Area of Science:

• Dermatopathology
• Oncology
• Genetics

Background:

• Intradermal nevi are common benign skin lesions.
• Intralymphatic nevus cell protrusion and lymphatic invasion are rare findings.
• Distinguishing benign from malignant lesions is crucial for patient management.

Purpose of the Study:

• To report a case of intradermal nevus with intralymphatic nevus cell protrusion and lymphatic invasion.
• To investigate the genetic basis of this rare finding.
• To emphasize the importance of accurate histopathological assessment.

Main Methods:

• Histopathological examination of a pigmented nodule.
• Immunohistochemical analysis of cellular characteristics.
• Next-generation sequencing for genetic mutation analysis (BRAF V600E).

Main Results:

• Histopathology confirmed an intradermal nevus with intralymphatic nevus cell protrusion and lymphatic invasion.
• Nevus cells exhibited characteristic morphology and immunohistochemistry.
• The BRAF V600E mutation was detected via next-generation sequencing.
• This represents the 27th reported case in the literature.

Conclusions:

• Intralymphatic nevus cell protrusion and lymphatic invasion in intradermal nevi are rare but benign findings.
• The presence of the BRAF V600E mutation may be associated with this phenomenon.
• Pathologists must consider the overall histological context to avoid misdiagnosis of malignancy.