Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Chronic Pancreatitis II: Collaborative Care

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Unmet needs of patients with cancer undergoing radiotherapy in Korea: A qualitative study.

European journal of oncology nursing : the official journal of European Oncology Nursing Society·2026

Same author

Evolution of treatment patterns and survival outcomes in non-metastatic rectal cancer: a 15-year real-world single-center analysis.

BMC cancer·2026

Same author

Overall Survival Among Patients With Hepatocellular Carcinoma Treated With External Beam Radiation Therapy: Individual Patient Data Outcomes From a Multinational Cohort.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026

Same author

Hypoglossal Nerve Stimulation Therapy for Pediatric Obstructive Sleep Apnea: A Meta-Analysis.

Biomedicines·2026

Same author

Cold-spot driven local failure after stereotactic body radiation therapy for colorectal liver metastases.

Frontiers in oncology·2026

Same author

Ultra-high dose rate electron FLASH beam irradiation using a modified clinical linear accelerator.

PloS one·2026

Search research articles

Related Experiment Video

Updated: Jun 12, 2026

Laparoscopic Radical Left Pancreatectomy for Pancreatic Cancer: Surgical Strategy and Technique Video

Laparoscopic Radical Left Pancreatectomy for Pancreatic Cancer: Surgical Strategy and Technique Video

Published on: June 6, 2020

Radiotherapy for Locally Advanced Pancreatic Cancer in the Modern Era: A Systematic Review and Meta-Analysis.

Sun Hyun Bae¹, Won Il Jang², Jeong Il Yu³

¹Department of Radiation Oncology, Soonchunhyang University College of Medicine, Bucheon 14584, Republic of Korea.

|September 27, 2025

Summary

Modern radiotherapy techniques show similar efficacy for locally advanced unresectable pancreatic cancer (LAPC). However, concurrent chemoradiotherapy and elective nodal irradiation increase hematologic toxicity risk, warranting cautious interpretation of results.

Keywords:

intensity-modulated radiotherapy modern radiotherapy pancreatic cancer particle beam therapy stereotactic radiotherapy

More Related Videos

Robot-Assisted Radical Antegrade Modular Pancreatosplenectomy Including Resection and Reconstruction of the Spleno-Mesenteric Junction

Robot-Assisted Radical Antegrade Modular Pancreatosplenectomy Including Resection and Reconstruction of the Spleno-Mesenteric Junction

Published on: January 3, 2020

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

Published on: September 24, 2020

Related Experiment Videos

Last Updated: Jun 12, 2026

Laparoscopic Radical Left Pancreatectomy for Pancreatic Cancer: Surgical Strategy and Technique Video

Laparoscopic Radical Left Pancreatectomy for Pancreatic Cancer: Surgical Strategy and Technique Video

Published on: June 6, 2020

Robot-Assisted Radical Antegrade Modular Pancreatosplenectomy Including Resection and Reconstruction of the Spleno-Mesenteric Junction

Robot-Assisted Radical Antegrade Modular Pancreatosplenectomy Including Resection and Reconstruction of the Spleno-Mesenteric Junction

Published on: January 3, 2020

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

An Orthotopic Resectional Mouse Model of Pancreatic Cancer

Published on: September 24, 2020

Area of Science:

Oncology
Radiation Oncology

Background:

Optimal treatment for locally advanced unresectable pancreatic cancer (LAPC) remains under investigation.
Evaluating the role of modern radiotherapy (RT) techniques in LAPC management is crucial.

Purpose of the Study:

To systematically review and meta-analyze the efficacy and toxicity of modern RT techniques for LAPC.
To compare intensity-modulated radiotherapy (IMRT), stereotactic body radiotherapy (SBRT), and particle beam therapy (PBT) in LAPC treatment.

Main Methods:

Systematic review and meta-analysis following PRISMA guidelines.
Included 53 observational studies with 2548 LAPC patients treated with IMRT, SBRT, or PBT.
Analyzed 2-year overall survival and acute hematologic toxicity (HT) rates.

Main Results:

Similar 2-year overall survival rates across IMRT, SBRT, and PBT (28%, 26%, 43% respectively).
Significant differences in acute hematologic toxicity (≥ grade 3): IMRT (23%), SBRT (4%), PBT (20%).
Concurrent chemoradiotherapy and elective nodal irradiation increased HT risk.

Conclusions:

Modern RT techniques demonstrate comparable efficacy for LAPC.
SBRT showed a lower rate of acute hematologic toxicity compared to IMRT and PBT.
Study limitations include single-arm designs and evolving chemotherapy regimens, necessitating cautious interpretation.