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Related Experiment Video

Updated: Jan 16, 2026

An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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Computational Drug Repurposing Across the Multiple Myeloma Spectrum: From MGUS to MM.

Kyriaki Savva1, Marilena M Bourdakou1, Dimitris Stellas2

  • 1Bioinformatics Department, The Cyprus Institute of Neurology and Genetics, Nicosia 2371, Cyprus.

Cancers
|September 27, 2025
PubMed
Summary

This study identifies potential repurposed drugs for multiple myeloma (MM) and its precursor stages, monoclonal gammopathy of unknown significance (MGUS) and smouldering multiple myeloma (SMM). The findings aim to accelerate new treatments for these B cell malignancies.

Keywords:
drug combinationsdrug repurposingmultiple myelomaprodromal stages

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Area of Science:

  • Hematology
  • Oncology
  • Pharmacology

Background:

  • Multiple myeloma (MM) is an incurable B cell malignancy originating from monoclonal gammopathy of unknown significance (MGUS) and progressing through smouldering multiple myeloma (SMM).
  • Despite treatment advances, MM remains a significant unmet medical need, driving the search for novel therapeutic strategies.
  • Drug repurposing offers a faster route to clinical application compared to de novo drug discovery.

Purpose of the Study:

  • To identify existing drugs that can be repurposed for treating different stages of multiple myeloma (MM), including its precursor conditions.
  • To develop a stage-specific drug repurposing strategy for MM using transcriptomics data.
  • To propose novel drug combinations for MM treatment.

Main Methods:

  • A comprehensive signature-based drug repurposing approach was employed, utilizing all publicly available bulk transcriptomics datasets for MGUS, SMM, and MM.
  • An in-house scoring scheme was developed for filtering and prioritizing candidate repurposed drugs.
  • A computational workflow was used to identify potential drug combinations with FDA-approved MM therapies.

Main Results:

  • The study identified 25 candidate repurposed drugs for MGUS, 23 for SMM, and 66 for MM.
  • Gene targets and functional terms were analyzed to provide insights into stage-specific mechanisms of myeloma.
  • Potential drug combinations were proposed, integrating repurposed candidates with existing MM treatments.

Conclusions:

  • The developed resource offers a stage-specific and transparent approach to drug repurposing and combination design for MM.
  • These findings are intended to accelerate the translation of research into clinical practice for earlier MM intervention.
  • The study aims to improve patient outcomes by providing novel therapeutic avenues for multiple myeloma and its precursor stages.