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The Usefulness of Indocyanine Green in Modern Gynecological Oncology-Analysis, Literature Review, and Future
Michał Kostrzanowski1, Grzegorz Ziółkowski1, Agata Mandes1
1Department of Gynecology and Gynecologic Oncology, Center of Postgraduate Medical Education, Cegłowska 80, 01-809 Warsaw, Poland.
Abstract:
Indocyanine green (ICG) is a fluorescent agent which is characterized by a wide range of applications in the proper visualization of the operating field, differentiation of vital structures, and localization of lesions to be excised. An investigation and overview of novel approaches of indocyanine green in modern gynecological oncology was conducted, including ovarian cancer surgery with its compartmental approach and compartmental surgery in endometrial cancer. Ureteral visualization and perfusion, lymphography, lymph node transfers, or the localization of anastomotic leakage in bowel surgery are examples of applications aimed at reducing the risk of surgical complications and improving the patients' quality of life. The general use of indocyanine green in lymph node detection, subcategorized and analyzed, is constantly improved and reviewed. A therapeutic approach with macromolecules is being tested in preclinical models. Early results could suggest the future application of indocyanine green not only in broad-sense imaging but also as a cytotoxic agent conjugated with macromolecules. Further studies on the application of indocyanine green in laparoscopy, open surgery, and finally as a curative cytotoxic agent are needed.
Insights
Indocyanine green (ICG) enhances surgical precision in gynecological oncology by improving visualization and localization. Future research explores its potential as a cytotoxic agent for cancer therapy.
Area of Science:
- Oncology
- Surgical Innovation
Background:
- Indocyanine green (ICG) is a vital fluorescent agent.
- ICG offers broad applications in surgical visualization, structure differentiation, and lesion localization.
Purpose of the Study:
- To investigate novel applications of ICG in modern gynecological oncology.
- To review ICG's role in ovarian and endometrial cancer surgery.
Main Methods:
- Overview of ICG applications in gynecological oncology.
- Analysis of ICG in ureteral visualization, lymphography, and bowel surgery.
Main Results:
- ICG aids in compartmental approaches for ovarian and endometrial cancer.
- ICG improves surgical safety by reducing complications and enhancing patient quality of life.
- ICG is crucial for lymph node detection and localization of anastomotic leakage.
Conclusions:
- ICG is a versatile tool in gynecological surgery, enhancing precision and patient outcomes.
- Preclinical models suggest ICG's future therapeutic potential as a cytotoxic agent.
- Further studies are needed to explore ICG in various surgical settings and as a curative agent.
