Contrast-Enhanced Mammography-Guided Biopsy in Patients with Extensive Suspicious Microcalcifications.

Area of Science:

• Radiology
• Oncology
• Medical Imaging

Background:

• Extensive suspicious microcalcifications pose diagnostic challenges in mammography.
• Accurate cancer diagnosis is crucial for timely treatment and improved patient outcomes.

Purpose of the Study:

• To evaluate the feasibility and effectiveness of contrast-enhanced mammography-guided biopsy (CEM-Bx) for diagnosing cancer in patients with extensive suspicious microcalcifications.
• To compare the cancer diagnostic rates (CDRs) of CEM-Bx with conventional mammography-guided biopsy (MG-Bx).

Main Methods:

• A study involving 61 women with extensive suspicious microcalcifications.
• Patients underwent either CEM-Bx (if enhancement was present) or conventional MG-Bx.
• Histological results and microcalcification characteristics were analyzed and compared between groups.

Main Results:

• CEM-Bx diagnosed cancer in 19 out of 26 patients, yielding a significantly higher CDR (73.08%) compared to MG-Bx (20%) in the control group (p < 0.01).
• CEM-Bx demonstrated cancer diagnostic rates of 81.8% for regional and 66.7% for segmental/diffuse microcalcifications.
• The overall CDR for the test group (31.4%) was higher than the control group (20%).

Conclusions:

• CEM-Bx is a safe and feasible biopsy method for extensive suspicious microcalcifications.
• CEM-Bx effectively targets enhanced areas, improving cancer detection rates.
• Larger prospective trials are recommended for widespread adoption.