Early-Life Hydrogen Sulfide Signaling as a Target for Cardiovascular-Kidney-Metabolic Syndrome Reprogramming.

Area of Science:

• Biochemistry
• Developmental Biology
• Physiology

Background:

• Hydrogen sulfide (H2S) is recognized as a crucial endogenous signaling molecule, impacting health and disease.
• The developmental origins of health and disease (DOHaD) framework suggests early-life H2S signaling disruptions contribute to later CKM syndrome.
• CKM syndrome involves chronic kidney disease, obesity, diabetes, and cardiovascular disease.

Purpose of the Study:

• To review the role of H2S in CKM syndrome programming.
• To explore the potential of H2S-based interventions for preventing CKM syndrome.
• To identify underexplored areas in H2S research related to DOHaD.

Main Methods:

• Literature review of preclinical and clinical studies.
• Analysis of animal model findings on maternal supplementation.
• Discussion of emerging research areas like gut microbiota and epigenetics.

Main Results:

• Maternal supplementation with sulfur-containing compounds (e.g., amino acids, N-acetylcysteine, H2S donors) in animal studies shows potential to reduce CKM risks in offspring.
• H2S plays a significant role in the developmental programming of CKM syndrome.
• Preclinical findings suggest H2S-targeting interventions can mitigate risks.

Conclusions:

• Targeting H2S signaling presents a promising strategy for early-life prevention of CKM syndrome.
• Further research is needed on gut microbiota, epigenetic mechanisms, and clinical translation.
• H2S interventions may offer broader potential for preventing other DOHaD-related chronic diseases.