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Immune Enhancement Effects and Extraction Optimization of Polysaccharides from Peristrophe roxburghiana
Yong Chen1, Zilong Zhao2, Yanyan Xu1
1College of Agriculture and Biology, Guangxi Minzu Normal University, Chongzuo 532200, China.
Antioxidants (Basel, Switzerland)
|September 27, 2025
Summary
This study optimized polysaccharide extraction from Peristrophe roxburghiana (CPPRs), revealing significant antioxidant and immune-enhancing properties. These findings suggest CPPRs are valuable for food and pharmaceutical applications.
Area of Science:
- Plant-derived polysaccharides
- Natural product chemistry
- Bioactive compounds
Background:
- Polysaccharides from Peristrophe roxburghiana (CPPRs) are under investigation for their bioactivity.
- Optimization of extraction processes is crucial for maximizing yield and purity.
Purpose of the Study:
- To optimize the extraction of polysaccharides from Peristrophe roxburghiana.
- To systematically investigate the physicochemical, structural, morphological, antioxidant, and immunomodulatory properties of CPPRs.
Main Methods:
- Box-Behnken design-response surface methodology for extraction optimization.
- Advanced techniques including FTIR, SEM, XRD, HPLC, rheology, and TGA for characterization.
- In vitro assays for antioxidant activity (ABTS, DPPH, Fe3+ reduction, red blood cell protection) and immunomodulatory effects (cytokine and NO secretion in macrophages).
Main Results:
- Optimal extraction conditions yielded 17.89% CPPRs.
- CPPRs are composed of arabinose, galactose, and glucose, exhibiting amorphous structure and low-viscosity gel properties.
- Significant in vitro antioxidant activity was observed, including ROS scavenging and protection against red blood cell oxidative damage.
- CPPRs promoted cytokine (TNF-α, IL-6, IL-10) and NO secretion in macrophages.
Conclusions:
- Optimized extraction yields high-quality polysaccharides from Peristrophe roxburghiana.
- CPPRs possess notable antioxidant and immune-enhancing bioactivities.
- CPPRs show potential as functional ingredients in the food and pharmaceutical industries.
