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The Female Reproductive Tract Microbiota and Endometrial Cancer: A Systematic Review.
Riccardo Vizza1, Francesco Belli1, Paolo Fabene2,3
1Unit of Obstetrics and Gynecology, Department of Surgery, Dentistry, Pediatrics, and Gynecology, AOUI Verona, University of Verona, 37125 Verona, Italy.
International Journal of Molecular Sciences
|September 27, 2025
Summary
Altered female genital tract microbiota, marked by lower Lactobacillus and higher pro-inflammatory bacteria, is linked to endometrial cancer (EC). This review highlights the association between these microbial shifts and EC development.
Area of Science:
- Gynecologic Oncology
- Microbiome Research
- Cancer Biology
Background:
- The gut microbiota is extensively studied, but the female reproductive tract microbiota's role in endometrial cancer (EC) remains under-explored.
- Understanding the microbial communities in the endometrium, cervix, and vagina is crucial for gynecologic cancer research.
Conclusions:
- The findings support a significant association between an altered female genital tract microbiota and endometrial cancer (EC).
- Despite limitations in causality due to observational designs and methodological heterogeneity, the identified microbial shifts are relevant to EC pathogenesis.
- Further research is warranted to elucidate causal mechanisms and explore therapeutic potential.
