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Effects of Rice Bran Supplementation on Metabolic Syndrome-Related Parameters: A Systematic Review and Meta-Analysis.
Sirapatsorn Tantayakhom1, Ratchanon Inpan1,2,3, Kantirat Yaja1,2
1Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
International Journal of Molecular Sciences
|September 27, 2025
Summary
Rice bran supplementation significantly improves key health markers for metabolic syndrome (MetS). This dietary strategy effectively lowers blood pressure, HbA1c, and LDL cholesterol while increasing HDL cholesterol.
Area of Science:
- Nutrition Science
- Metabolic Health
- Dietary Interventions
Background:
- Metabolic syndrome (MetS) is a cluster of conditions increasing cardiovascular and diabetes risk.
- Rice bran, rich in bioactive compounds and fiber, shows potential health benefits.
- The specific impact of rice bran on MetS components requires comprehensive evaluation.
Purpose of the Study:
- To systematically evaluate the effects of rice bran supplementation on anthropometric measures, blood pressure, glycemic control, and lipid profiles in individuals with MetS.
- To synthesize evidence from randomized controlled trials (RCTs) through a meta-analysis.
Main Methods:
- Systematic literature search of major databases (PubMed/Medline, Scopus, Cochrane Library, Embase) up to January 2025.
- Inclusion of 26 RCTs with 1255 participants (642 in rice bran groups, 613 in controls).
- Meta-analysis using weighted mean differences (WMDs) to assess the impact of rice bran.
Main Results:
- Significant reductions observed in systolic blood pressure (WMD: -3.336 mmHg; p = 0.0006) and diastolic blood pressure (WMD: -3.145 mmHg; p = 0.015).
- Improved glycemic control with a significant decrease in HbA1c (WMD: -0.199%; p = 0.003).
- Favorable changes in lipid profiles: reduced total cholesterol (WMD: -13.594 mg/dL; p < 0.0001), reduced LDL cholesterol (WMD: -14.580 mg/dL; p < 0.0001), and increased HDL cholesterol (WMD: 3.074 mg/dL; p = 0.007).
Conclusions:
- Rice bran supplementation demonstrates significant benefits in managing key risk factors associated with metabolic syndrome.
- These findings support rice bran as a promising natural dietary intervention for MetS management and prevention.
- Further research may explore optimal dosages and long-term effects of rice bran in diverse populations.
