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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
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Related Experiment Video

Updated: Jan 16, 2026

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
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Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease

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Comprehensive Profiling Identifies Circulating microRNA Dysregulation in Vietnamese Patients with Heart Failure.

Bao-Quoc Vu1, Phuong Anh Huynh1, Nhu Nhat Quynh Nguyen1

  • 1Center for Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City 70000, Vietnam.

International Journal of Molecular Sciences
|September 27, 2025
PubMed
Summary
This summary is machine-generated.

This study reveals distinct circulating microRNA (miRNA) profiles in heart failure (HF) patients. Identifying these specific miRNAs may lead to new diagnostic tools for this complex cardiac condition.

Keywords:
circulating miRNAsheart failurenext generation sequencing

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Area of Science:

  • Cardiology
  • Molecular Biology
  • Genomics

Background:

  • Heart failure (HF) is a global health concern with significant morbidity and mortality.
  • MicroRNAs (miRNAs) are crucial for cardiac homeostasis, but their circulatory profiles in HF remain underexplored.
  • Dysregulation of miRNAs is implicated in cardiac dysfunction.

Purpose of the Study:

  • To comprehensively profile circulating microRNAs (miRNAs) in patients with heart failure (HF).
  • To identify specific miRNAs dysregulated in HF patients compared to non-HF controls.
  • To explore potential pathways associated with these circulating miRNAs.

Main Methods:

  • Plasma samples from 24 HF patients and 24 age/sex-matched controls were analyzed using next-generation sequencing for miRNA profiling.
  • A total of 1391 miRNAs were detected.
  • Target gene prediction and pathway enrichment analyses were performed.

Main Results:

  • Eight miRNAs were found to be significantly dysregulated between HF and non-HF groups.
  • Seven additional miRNAs were uniquely detected in HF patients.
  • Enriched pathways included vascular development, cell cycle, and transcriptional activity.

Conclusions:

  • Circulating miRNA expression profiles differ between HF patients and healthy individuals.
  • Specific miRNAs are dysregulated in HF, offering potential biomarkers.
  • These findings contribute to understanding the molecular mechanisms of HF.