Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Biomarker analysis from patients with metastatic PDAC treated with TGFβ antibody, NIS793, plus abraxane+gemcitabine vs. abraxane+gemcitabine alone in a phase II, open label, randomized study.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Same author

Predicting recurrence patterns and outcomes following resection of pancreatic ductal adenocarcinoma: a contemporary real-world data cohort study.

Annals of medicine and surgery (2012)·2026

Same author

Trends in lung cancer incidence and stage at diagnosis in Singapore: a population-based joinpoint regression analysis by age, sex, and smoking status.

The Lancet regional health. Western Pacific·2026

Same author

Effects of current smoking on treatment outcomes in metastatic and locally advanced pancreatic carcinoma: a retrospective cohort study using the international PURPLE pancreas cancer registry.

Journal of gastrointestinal oncology·2025

Same author

Discovery and Characterization of VPRBP/DCAF1 Kinase Inhibitor Analogs as Microtubular Destabilizing Agents with Potent Antimyeloma Activity.

Molecular cancer therapeutics·2025

Same author

MMPs and NETs are detrimental in CNS-tuberculosis with MMP Inhibition in CNS-tuberculosis mice improving survival.

Journal of neuroinflammation·2025

Search research articles

Related Experiment Video

Updated: Jan 16, 2026

Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid Models

Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid Models

Published on: January 14, 2020

Functional Precision in Pancreatic Cancer: Redefining Biomarkers with Patient-Derived Organoids.

Claire Alexandra Chew^1,2, Cheng Mun Wun^1,2, Yi Fang Lee^1,2

¹Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.

International Journal of Molecular Sciences

|September 27, 2025

Summary

Pancreatic cancer research needs better biomarkers. Patient-derived organoids (PDOs) offer a dynamic platform for functional precision medicine, improving therapeutic strategies for pancreatic ductal adenocarcinoma (PDAC).

Keywords:

biomarkers chemosensitivity pancreatic ductal adenocarcinoma patient-derived organoids precision medicine

More Related Videos

Author Spotlight: Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue

Author Spotlight: Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue

Published on: May 26, 2023

Organotypic Slice Cultures as Preclinical Models of Tumor Microenvironment in Primary Pancreatic Cancer and Metastasis

Organotypic Slice Cultures as Preclinical Models of Tumor Microenvironment in Primary Pancreatic Cancer and Metastasis

Published on: June 22, 2021

Related Experiment Videos

Last Updated: Jan 16, 2026

Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid Models

Isolation and Characterization of Patient-derived Pancreatic Ductal Adenocarcinoma Organoid Models

Published on: January 14, 2020

Author Spotlight: Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue

Author Spotlight: Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue

Published on: May 26, 2023

Organotypic Slice Cultures as Preclinical Models of Tumor Microenvironment in Primary Pancreatic Cancer and Metastasis

Organotypic Slice Cultures as Preclinical Models of Tumor Microenvironment in Primary Pancreatic Cancer and Metastasis

Published on: June 22, 2021

Area of Science:

Oncology
Biomarker Discovery
Translational Medicine

Background:

Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDAC), has a poor prognosis despite treatment advances.
Current molecular subtypes lack clinical utility for real-time treatment decisions.
Clinically actionable biomarkers for PDAC are urgently needed.

Purpose of the Study:

To review limitations of current PDAC biomarker strategies.
To propose a functional reframing of biomarker development using patient-derived organoids (PDOs).
To highlight PDOs' potential in advancing precision medicine for PDAC.

Main Methods:

Review of current literature on PDAC biomarkers and patient-derived organoids.
Exploration of four key domains of PDO application: drug response phenotyping, modeling chemoresistance, incorporating tumor microenvironment, and functional profiling (proteomics, metabolomics).

Main Results:

Current subtype classifications offer limited prognostic value and do not guide treatment effectively.
Patient-derived organoids (PDOs) serve as dynamic platforms for capturing clinically relevant biology.
PDOs enable functional profiling, including drug response, chemoresistance, and tumor microenvironment interactions.

Conclusions:

Patient-derived organoids (PDOs) represent a promising functional approach to biomarker development in PDAC.
PDOs facilitate a shift from static tumor avatars to dynamic platforms for personalized medicine.
Functional precision medicine using PDOs may lead to more tailored and effective treatment strategies for pancreatic cancer.