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Updated: Jan 16, 2026

Investigating the Alleviating Effects of Bacillus cereus Administration on Colitis through Gut Microbiota Modulation
Published on: July 27, 2022
Lactobacillus fermentum Inhibits the Development of Colitis by Regulating the Intestinal Microbiota and Metabolites
Xiaoyan You1, Pengcheng Shi1, Wenjing Liu2
1Henan Engineering Research Center of Food Microbiology, College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471023, China.
None:
Ulcerative colitis (UC) is a chronic inflammatory disorder difficult to cure with current treatments. Therefore, preventive interventions for UC are crucial. This research investigated the intervention potential of Lactobacillus (L.) fermentum S1 derived from a cat in reducing dextran sulfate sodium (DSS)-triggered UC. Through a combination of physiological, microbiological, and metabolomic analyses, we demonstrated that preventive supplementation with L. fermentum S1 significantly mitigated DSS-triggered body weight loss, colon shortening, intestinal barrier (IB) dysfunction, and inflammatory reaction. L. fermentum S1 modulated gut microbiota (GM) components and elevated short-chain fatty acids generation. Beneficial genera were abundant (Akkermansia, Ligilactobacillus, Turicibacter, and Prevotella_9) while suppressing pathogenic taxa (Parabacteroides and Acinetobacter). Furthermore, L. fermentum S1 increased the amount of the anti-inflammatory metabolite hecogenin within the intestines. Spearman's correlation analysis exhibited significant associations between microbial shifts and metabolite profiles, suggesting that microbiota-derived metabolites can mediate their therapeutic effects. These outcomes indicate the potential of L. fermentum S1 as a new dietary supplement and provide a theoretical basis for UC prevention.
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