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Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
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Development of an Economical DNA Delivery System by "Acufection" and its Application to Skin Research
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Advances in Psoriasis Research: Decoding Immune Circuits and Developing Novel Therapies.

Lanying Wang1,2, Ruiling Liu1,2, Yulu Tang1,2

  • 1Joint National Laboratory for Antibody Drug Engineering, Henan University School of Medicine, Kaifeng 475004, China.

International Journal of Molecular Sciences
|September 27, 2025
PubMed
Summary

Psoriasis, an autoimmune skin disease, involves the IL-23/IL-17 axis and immune cell interactions. Emerging therapies show promise for long-term remission but require further research for optimal safety and efficacy.

Keywords:
CAR-T cell therapyIL-23/IL-17 axisbiologicalspsoriasistargeted therapy

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Area of Science:

  • Immunodermatology
  • Autoimmune diseases
  • Chronic inflammatory conditions

Background:

  • Psoriasis is a chronic autoimmune skin disease with systemic complications impacting quality of life.
  • Disease pathogenesis involves the IL-23/IL-17 axis, immune cell dysregulation, genetic factors, and environmental triggers.
  • Current treatments offer symptom control but not a cure, facing challenges in cost, safety, efficacy, and targeting precision.

Purpose of the Study:

  • To review recent mechanistic insights into psoriasis, focusing on microbial, innate, and adaptive immunity interplay.
  • To evaluate emerging therapies for psoriasis, including biologics, small molecules, CAR T-cell therapy, and RNA interference strategies.
  • To assess the potential of these novel approaches in personalized treatment and achieving long-term remission.

Main Methods:

  • Comprehensive literature review of recent advances in psoriasis research.
  • Analysis of novel mechanisms, efficacy, safety, and targeting accuracy of emerging therapies.
  • Evaluation of personalized medicine strategies for psoriasis management.

Main Results:

  • The IL-23/IL-17 axis and immune cell interactions are central to psoriasis development.
  • Emerging therapies demonstrate novel mechanisms but present challenges in efficacy, safety, and precision.
  • Personalized treatment approaches hold potential for achieving long-term psoriasis remission.

Conclusions:

  • Understanding the interplay of microorganisms and immunity is crucial for psoriasis pathogenesis.
  • Emerging therapies offer new avenues for psoriasis management, requiring careful evaluation.
  • Precision medicine approaches are essential for future psoriasis treatment and achieving sustained remission.