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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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The Tumor Microenvironment02:17

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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Related Experiment Video

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Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
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Tumor Innervation: From Bystander to Emerging Therapeutic Target for Cancer.

Zoey Zeyuan Ji1, Max Kam-Kwan Chan1, Philip Chiu-Tsun Tang1

  • 1Department of Anatomical and Cellular Pathology, State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong, Hong Kong.

International Journal of Molecular Sciences
|September 27, 2025
PubMed
Summary
This summary is machine-generated.

Tumor denervation targets cancer-associated nerves, impacting pain, growth, and metastasis. Novel strategies, including Macrophage to Neuron-like cell Transition (MNT), offer new therapeutic avenues for solid tumors.

Keywords:
denervation therapytumor innervationtumor–nerve crosstalk

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Area of Science:

  • Oncology
  • Neuroscience
  • Cancer Biology

Background:

  • Innervation is prevalent in diseased tissues, particularly in cancer.
  • Tumor-associated nerves influence cancer pain, progression, metastasis, and drug resistance.
  • Nerves interact with cancer cells and the tumor microenvironment via neurotrophic factors.

Purpose of the Study:

  • To review the latest research on tumor denervation.
  • To explore molecular mechanisms and innovative denervation strategies.
  • To identify novel therapeutic targets for solid tumors.

Main Methods:

  • Dissection of transcriptome dynamics in cancer-associated neurons.
  • Single-cell resolution analysis of neuronal changes.
  • Systematic review of current denervation research.

Main Results:

  • Identification of novel therapeutic targets for tumor denervation.
  • Discovery of the Macrophage to Neuron-like cell Transition (MNT) phenomenon.
  • Understanding of molecular interactions between nerves and cancer cells.

Conclusions:

  • Tumor denervation presents a promising therapeutic strategy for solid tumors.
  • Targeting tumor-associated nerves can inhibit cancer progression and enhance treatment efficacy.
  • Further research into denervation mechanisms and strategies may lead to novel cancer therapies.