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Antibiotic Dereplication Using the Antibiotic Resistance Platform

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"Dusting Off the Cobwebs": Rethinking How We Use New Antibiotics.

Jacob Myles Keck¹, Jacob Schultz², Alina Viteri¹

¹Department of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.

Antibiotics (Basel, Switzerland)

|September 27, 2025

Summary

Antimicrobial resistance is a growing global threat. Judicious use of novel antibiotics, guided by stewardship programs, is crucial for effective treatment and innovation.

Keywords:

antimicrobial resistance antimicrobial stewardship global one health multidrug-resistant organisms

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Area of Science:

Infectious Diseases
Pharmacology
Public Health

Background:

Escalating antimicrobial resistance (AMR) threatens modern medicine.
Traditional antibiotics are failing against multidrug-resistant (MDR) pathogens, increasing mortality and healthcare costs.
Antimicrobial stewardship must adapt to include novel agents.

Purpose of the Study:

To highlight the challenge of novel antibiotic underutilization.
To propose strategies for appropriate empiric use of new antimicrobial agents.
To emphasize the need for a coordinated global approach to AMR.

Main Methods:

Literature review and synthesis of current challenges in antimicrobial stewardship.
Analysis of the role of novel antibiotics in combating MDR infections.
Discussion of strategies for optimizing the deployment of new antimicrobial agents.

Main Results:

Novel antibiotics can improve outcomes against MDR organisms when used empirically.
Underutilization of new agents limits patient benefit and pharmaceutical innovation.
Effective stewardship requires integrating local epidemiology, risk stratification, and diagnostics.

Conclusions:

Optimizing the use of novel antimicrobials is essential for combating AMR.
Stewardship programs need to incorporate strategies for empiric use of new agents.
Global collaboration linking stewardship, innovation, and policy is critical.