Utilization of a Multi-Tissue Extracellular Matrix in Complex Wound Care in Gaza: A Case Series

Area of Science:

• Regenerative Medicine
• Trauma Surgery
• Wound Healing

Background:

• Complex ballistic and blast injuries present significant challenges in conflict zones.
• Standard wound care may be insufficient for severe soft tissue trauma.
• Austere conditions limit access to advanced medical supplies.

Purpose of the Study:

• To assess the feasibility and outcomes of using multi-tissue extracellular matrix (ECM) powder.
• To evaluate ECM's efficacy as an adjunct to standard wound care in a conflict zone.
• To examine granulation, wound closure, and complication rates in patients with severe injuries.

Main Methods:

• Retrospective observational case series at European Gaza Hospital (April-June 2024).
• Fifteen patients with high-energy soft tissue injuries received ECM powder (XCellistem™) post-debridement.
• Data collected from operative reports, wound documentation, and clinical follow-up.

Main Results:

• Granulation tissue observed by day 7 in 12 out of 15 patients.
• Wound closure achieved in 13 patients via grafting, flap coverage, or secondary intention.
• No adverse reactions to ECM powder were reported during the study period.

Conclusions:

• Multi-tissue ECM powder is feasible and safe in austere environments.
• ECM powder demonstrated potential to support wound healing in severely injured patients.
• Its properties make it a promising adjunct for surgical care in resource-constrained settings.