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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Related Experiment Video

Updated: Jan 16, 2026

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Gut Microbiome and Intestinal Colonization with Multidrug-Resistant Strains of Enterobacterales: An Interplay Between

Béla Kocsis1, Dóra Szabó1,2,3, László Sipos2

  • 1Institute of Medical Microbiology, Semmelweis University, 1089 Budapest, Hungary.

Antibiotics (Basel, Switzerland)
|September 27, 2025
PubMed
Summary

Multidrug-resistant (MDR) Enterobacterales colonization is influenced by gut microbiome composition. A high abundance of Enterobacterales correlates with MDR strains, while Lachnospiraceae family indicates protection.

Keywords:
carbapenem-resistant Escherichia colicarbapenem-resistant Klebsiella pneumoniaegut microbiomeintestinal colonizationmultidrug-resistant Enterobacterales

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Area of Science:

  • Microbiology
  • Gastroenterology
  • Infectious Diseases

Background:

  • The gut harbors diverse bacteria, with multidrug-resistant (MDR) Enterobacterales acting as reservoirs for infection.
  • Interactions between the gut microbiome and colonizing Enterobacterales impact long-term colonization.

Purpose of the Study:

  • To review current data on MDR Enterobacterales intestinal colonization.
  • To explore correlations between colonization and the gut microbiome.

Main Methods:

  • Narrative review of existing literature.
  • Analysis of microbiome composition in relation to MDR Enterobacterales carriage.

Main Results:

  • Lachnospiraceae family abundance is associated with protection against MDR Enterobacterales colonization.
  • High Enterobacterales abundance correlates with MDR Enterobacterales colonization.
  • Reduced gut microbiome alpha-diversity observed in liver transplant patients carrying MDR Enterobacterales.

Conclusions:

  • MDR Enterobacterales colonization is multifactorial, involving the pathogen, host factors, and exogenous influences.
  • Gut microbiome composition, particularly the dominance of Lachnospiraceae or Enterobacterales, plays a crucial role in colonization resistance.