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Therapeutic Plasma Exchange in Intensive Care Units-A 5-Year Multicenter Retrospective Study
Daria Syguła1, Paulina Kluszczyk1, Wiktor Wagner2
1Student Scientific Society, Department of Lung Diseases and Tuberculosis, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Medyków 14 St., 40-752 Katowice, Poland.
None:
(1).
Background:
Therapeutic plasma exchange (TPE) is a method of extracorporeal plasma filtration designed to remove immunoglobulins and pro-inflammatory factors as pathogenesis of numerous diseases. Procedures are performed in intensive care units (ICUs); however, the complications and treatment outcomes remain unclear. The aim of the study was to evaluate clinical outcomes and identify risk factors of complications associated with TPE. (2).
Methods:
In this multi-center, retrospective, 5-year cohort study, we analyzed a database of 56 adult ICU patients who had undergone TPE at two academic hospitals and one regional hospital. (3).
Results:
In our study, the median APACHE II was 7.5 IQR 12.5 (4-16.5) and SOFA score was 2 IQR 4 (1-5). In the multivariate analysis, the APACHE II (p = 0.043) and SOFA score (p = 0.046) were the predictors of prolonged length of stay. The SOFA score was a predictor of hospital-acquired infection (HAI) (p = 0.011). Multivariate logistic regression revealed age (p = 0.011), SOFA (p = 0.011), and APACHE II score (p = 0.032) as independent predictors of the development of shock as a TPE complication. (4).
Conclusions:
Our results suggest that the SOFA and APACHE II scores are significant predictors of the length of hospitalization and the occurrence of shock. In addition, the SOFA score was a predictor of HAI in patients treated TPE in ICU.
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