Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Introduction to Fibroblasts01:09

Introduction to Fibroblasts

3.8K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intra-CNS AAV9-<i>GBA1</i> delivery yields species and route of administration differences in safety and transgene expression.

Molecular therapy. Advances·2026
Same author

Outcome of metastatic non-rhabdomyosarcoma soft tissue sarcoma in children and young adults treated on children's oncology group ARST0332 trial.

Journal of the National Cancer Institute·2026
Same author

A modified Delphi consensus on tenosynovial giant cell tumour and giant cell tumour of bone : a report from the Birmingham Orthopaedic Oncology Meeting (BOOM).

The bone & joint journal·2026
Same author

Complications of PI to PIII hemipelvic resections for intermediate and malignant tumours : a systematic review and meta-analysis.

Bone & joint open·2026
Same author

Long-term results of 157 cemented endoprosthetic reconstructions for tumors of the humerus: a 30-year experience.

JSES international·2026
Same author

The Cancer Symposium: a focus on cancers of the head and neck.

British dental journal·2026

Related Experiment Video

Updated: Jan 16, 2026

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.5K

Non-Ossifying Fibromas: A 2025 Review.

Kyle Walker1, Jimmy B Smith1, Niket Todi1

  • 1Department of Orthopaedic Surgery, UC Davis Health, Sacramento, CA 95817, USA.

Journal of Clinical Medicine
|September 27, 2025
PubMed
Summary
This summary is machine-generated.

This review details non-ossifying fibromas (NOFs), common benign bone lesions in children. Understanding their epidemiology, imaging, and management aids clinicians in preventing unnecessary interventions.

Keywords:
Pediatric Orthopedicsbenign bone lesionnon-ossifying fibroma

More Related Videos

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
04:04

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Published on: August 15, 2025

371
An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
03:53

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Published on: October 10, 2025

442

Related Experiment Videos

Last Updated: Jan 16, 2026

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

2.5K
Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection
04:04

Lateral Molar Approach-Driven Transoral Endoscopic Procedure for Benign Infratemporal Fossa Tumor Resection

Published on: August 15, 2025

371
An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
03:53

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas

Published on: October 10, 2025

442

Area of Science:

  • Pediatric Orthopedics
  • Skeletal Radiology
  • Pediatric Pathology

Background:

  • Non-ossifying fibromas (NOFs) are common, benign bone lesions in pediatric populations.
  • These self-limiting lesions constitute a significant portion of skeletal abnormalities in children and adolescents.

Purpose of the Study:

  • To provide a comprehensive review of incidentally found bone lesions in children and adolescents, focusing on NOFs.
  • To integrate historical perspectives with current diagnostic and management strategies for NOFs.
  • To assist clinicians in optimizing diagnostic and treatment protocols for NOFs.

Main Methods:

  • Literature review encompassing historical descriptions, epidemiological data, histopathology, and advanced imaging findings of NOFs.
  • Analysis of diagnostic criteria and current management strategies for NOFs.
  • Exploration of emerging molecular insights related to NOFs.

Main Results:

  • NOFs are benign, self-limiting lesions with a well-documented history and characteristic features.
  • Key epidemiologic, histopathologic, and advanced imaging findings are outlined.
  • Current diagnostic criteria and management options are discussed, alongside novel molecular discoveries.

Conclusions:

  • A thorough understanding of NOFs is crucial for accurate diagnosis and effective management in pediatric patients.
  • This review aims to reduce unnecessary interventions by providing clinicians with comprehensive knowledge of NOFs.
  • Integrating historical context with modern insights enhances clinical decision-making for NOFs.