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Related Experiment Video

Updated: Jan 16, 2026

Evaluation of Respiratory Muscle Activation Using Respiratory Motor Control Assessment RMCA in Individuals with Chronic Spinal Cord Injury
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Respiratory Muscle Strength in Rheumatoid Arthritis.

Melanie Berger1,2, Maximilian Zimmermann1,2, Leon Thomas2

  • 1Department of Pneumonology, Cologne Merheim Hospital, Kliniken der Stadt Köln gGmbH, University Witten/Herdecke, 51109 Cologne, Germany.

Journal of Clinical Medicine
|September 27, 2025
PubMed
Summary
This summary is machine-generated.

Rheumatoid arthritis patients may experience reduced respiratory muscle strength, though not statistically significant in this study. Handgrip strength was notably lower in RA patients, correlating with respiratory function.

Keywords:
PImaxhandgrip strengthrespiratory muscle strengthrheumatoid arthritissarcopenia

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Area of Science:

  • Pulmonology
  • Rheumatology
  • Musculoskeletal Health

Background:

  • Rheumatoid arthritis (RA) is recognized for its impact on the musculoskeletal system, potentially leading to sarcopenia.
  • The specific role of respiratory muscle involvement in RA patients remains largely unexplored.
  • Understanding respiratory muscle strength is crucial for a comprehensive assessment of RA's systemic effects.

Purpose of the Study:

  • To prospectively compare respiratory muscle strength and handgrip strength between RA patients and matched controls.
  • To investigate potential correlations between respiratory muscle strength, handgrip strength, and functional capacity (6-minute walking distance) in RA.
  • To explore the prevalence of reduced respiratory muscle strength in RA patients, even with low disease activity.

Main Methods:

  • A prospective, exploratory, single-center, matched-pair analysis was conducted.
  • Participants included 36 RA patients with low disease activity and 36 healthy controls, matched for key characteristics.
  • Primary endpoint: Maximal inspiratory mouth pressure (PImax). Secondary endpoints included handgrip strength and 6-minute walking distance.

Main Results:

  • Maximal inspiratory mouth pressure (PImax) tended to be lower in RA patients but did not reach statistical significance.
  • RA patients showed a higher frequency of PImax values below the normal range (OR 1.74).
  • RA patients exhibited significantly lower handgrip strength compared to controls (-5.97 kg). PImax correlated with handgrip strength and 6-minute walking distance in both groups.

Conclusions:

  • While the primary endpoint was not met, an impairment of respiratory muscle strength in RA patients cannot be ruled out, particularly in a subset.
  • Reduced handgrip strength is evident in RA patients, suggesting broader muscle involvement.
  • Further research is warranted, including studies with RA patients exhibiting higher disease activity, to fully elucidate respiratory muscle function in RA.