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COPD: Pathogenesis and Clinical Features01:20

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Correlations Between Inflammatory Biomarkers and COPD Severity in a Real-Life Setting.

Elena-Andreea Moaleș1,2, Lucia Corina Dima-Cozma1,3, Cristina Andreea Adam1,3

  • 1Department of Medical Specialities I, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, University Street No. 16, 700115 Iași, Romania.

Journal of Clinical Medicine
|September 27, 2025
PubMed
Summary
This summary is machine-generated.

The neutrophil-to-lymphocyte ratio (NLR) is a valuable biomarker for assessing chronic obstructive pulmonary disease (COPD) severity. This simple blood test can help predict disease progression and guide treatment decisions for COPD patients.

Keywords:
chronic obstructive pulmonary disease (COPD)inflammationinterleukin 1-beta (IL-1beta)interleukin 6 (IL-6)interleukin 8 (IL-8)lymphocyte/HDL-C ratio (LHR)neutrophil-to-lymphocyte ratio (NLR)platelet-to-lymphocyte ratio (PLR)tumor necrosis factor alpha (TNF-alpha)

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Area of Science:

  • Pulmonary Medicine
  • Inflammation Research
  • Biomarker Discovery

Background:

  • Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality globally.
  • Identifying accessible prognostic biomarkers is crucial for managing COPD.
  • Inflammation plays a key role in COPD development and progression.

Purpose of the Study:

  • To evaluate inflammatory markers for estimating COPD severity (GOLD stages 1-4).
  • To guide management and treatment decisions in COPD patients.
  • To reduce exacerbations and mortality in COPD.

Main Methods:

  • Descriptive observational, cross-sectional study of 100 stable COPD patients.
  • Standard clinical examination, lung function tests, and blood inflammation panel.
  • Analysis of parameters including IL-1 beta, IL-6, IL-8, and neutrophil-to-lymphocyte ratio (NLR).

Main Results:

  • NLR, IL-1 beta, IL-6, IL-8, male sex, smoking status, BMI, and nocturnal heart rate correlated with COPD severity.
  • NLR showed significant correlation with 6-minute walk test distance and FEV1/FVC ratio.
  • IL-6 correlated with pack-years and FVC (%); IL-8 correlated with biomass fuel exposure.

Conclusions:

  • NLR is a simple, accessible, and informative biomarker for COPD severity and functional decline.
  • Integrating NLR into routine assessments can improve COPD prognosis and clinical decision-making.
  • Further multicenter studies are needed to confirm these findings.