Analysis of 24-Hour Blood Pressure Profile and Antihypertensive Therapy in Male Heart Transplant Patients

Wioletta Raczyńska1, Alicja Radtke-Łysek1, Michał Bohdan1

  • 1First Department of Cardiology, Medical University of Gdańsk, 80-952 Gdańsk, Poland.

Journal of Clinical Medicine
|September 27, 2025
PubMed

Insights

Heart transplant recipients have higher rates of hypertension and abnormal night-time blood pressure patterns compared to controls. Tailored hypertension management, including chronotherapy, is crucial for these patients.

Area of Science:

  • Cardiology
  • Nephrology
  • Transplantation Medicine

Background:

  • Improved survival post-heart transplantation is noted, yet hypertension remains a significant complication.
  • Understanding the 24-hour blood pressure profile in heart transplant recipients is essential for effective management.

Purpose of the Study:

  • To evaluate the 24-hour blood pressure profile in heart transplant recipients.
  • To compare hypertension prevalence and treatment in heart transplant recipients versus a control group.

Main Methods:

  • Retrospective analysis of 26 male heart transplant recipients and 39 male controls.
  • Data collection included 24-hour ambulatory blood pressure monitoring, laboratory tests, and medical history.

Main Results:

  • Hypertension diagnosed in 76.9% of heart transplant recipients vs. 56.4% of controls.
  • Elevated nocturnal diastolic blood pressure (≥70 mmHg) in 76.9% of recipients.
  • Significantly higher prevalence of reverse dippers and isolated nocturnal hypertension in recipients.

Conclusions:

  • Heart transplant recipients exhibit distinct 24-hour blood pressure patterns, including nocturnal hypertension.
  • A personalized approach to hypertension management, incorporating chronotherapy, is necessary for heart transplant recipients.

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