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Sleeve Gastrectomy in Mice using Surgical Clips
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Gender Differences in Weight Loss Extent Following Bariatric Surgery.

Santo Colosimo1, Federica Sileo1,2, Andrea Gambetti3

  • 1Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, 20133 Milan, Italy.

Journal of Clinical Medicine
|September 27, 2025
PubMed
Summary
This summary is machine-generated.

Men achieved greater absolute weight loss after sleeve gastrectomy, but relative weight loss was similar between genders. This highlights potential gender disparities in metabolic-bariatric surgery (MBS) access and outcomes.

Keywords:
gender differencessleeve gastrectomyweight loss

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Area of Science:

  • Bariatric Surgery
  • Obesity Medicine
  • Gender Health Disparities

Background:

  • Metabolic-bariatric surgery (MBS) is effective for severe obesity, yet gender disparities affect access and outcomes.
  • Men have higher baseline weight and comorbidity but are underrepresented in MBS.
  • Evidence on gender-specific outcomes, especially in Mediterranean populations, needs clarification.

Purpose of the Study:

  • To assess gender differences in weight loss after sleeve gastrectomy in an Italian cohort.
  • To evaluate outcomes under current multidisciplinary protocols.
  • To inform equitable surgical access and postoperative care.

Main Methods:

  • Prospective observational study of 131 patients (22 males, 109 females) undergoing sleeve gastrectomy.
  • Assessment of anthropometric and metabolic parameters at baseline and 12 months.
  • Comparison of absolute weight loss, total weight loss percentage (TWL%), excess weight loss percentage (EWL%), and waist circumference using t-tests and regression models.

Main Results:

  • Men achieved significantly greater absolute weight loss (-36.6 kg) vs. women (-31.2 kg) at 12 months (p=0.028).
  • No significant gender differences were found in TWL%, EWL%, or waist circumference reduction.
  • Gender predicted absolute weight loss but not proportional weight loss; both genders reached similar clinically significant weight loss thresholds.

Conclusions:

  • Men experienced greater absolute weight loss, but relative weight loss was comparable between genders post-sleeve gastrectomy.
  • Gender disparities in MBS utilization persist.
  • Findings underscore the need for equitable access and personalized postoperative care in bariatric surgery.