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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

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Correction: Iliuta et al. Impact of Pulmonary Hypertension on Mortality After Surgery for Aortic Stenosis. <i>Medicina</i> 2022, <i>58</i>, 1231.

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Murine Superficial Lymph Node Surgery
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Rethinking Lymphadenectomy in Cutaneous Melanoma: From Routine Practice to Selective Indication: A Narrative Review.

Matteo Matteucci1, Antonio Pesce2, Salvatore Guarino3

  • 1Department of General Surgery, University of Milan, 20122 Milan, Italy.

Medicina (Kaunas, Lithuania)
|September 27, 2025
PubMed
Summary
This summary is machine-generated.

Complete lymph node dissection (CLND) is no longer standard for melanoma staging. Sentinel lymph node biopsy (SLNB) is now preferred, reserving CLND for select high-risk cases based on new evidence.

Keywords:
complete lymphadenectomycutaneous melanomaelective lymph node dissectionlymph node dissectionnarrative reviewsentinel lymph node biopsy

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Area of Science:

  • Oncology
  • Dermatology
  • Surgical Oncology

Background:

  • Lymph node management in cutaneous melanoma has evolved significantly.
  • The approach has shifted from routine complete lymph node dissection (CLND) to selective, individualized strategies.

Purpose of the Study:

  • To review the historical evolution, current evidence, and clinical guidelines for lymphadenectomy in Stage III melanoma.
  • To analyze the impact of recent clinical trials on surgical management decisions.

Main Methods:

  • A comprehensive literature search was performed using PubMed, Scopus, and Web of Science.
  • The review focused on randomized controlled trials, meta-analyses, and international guidelines published within the last 15 years.

Main Results:

  • Pivotal trials (MSLT-II, DeCOG-SLT) showed no survival benefit for immediate CLND after a positive sentinel lymph node biopsy (SLNB), highlighting surgical morbidity.
  • Current guidelines (AIOM, ESMO, NCCN) recommend SLNB for nodal staging, with CLND reserved for specific high-risk scenarios.

Conclusions:

  • Lymphadenectomy in melanoma is increasingly selective, influenced by tumor burden, nodal status, and systemic therapy response.
  • Sentinel lymph node biopsy (SLNB) is the standard for staging, while complete lymph node dissection (CLND) is not routinely performed.
  • Future surgical strategies will be refined by ongoing clinical trials and the integration of immunotherapy.