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Echinops as a Source of Bioactive Compounds-A Systematic Review
Simona Ivanova1, Alexandra Ivanova1, Mina Todorova1
1Department of Organic Chemistry, Faculty of Chemistry, University of Plovdiv, 4000 Plovdiv, Bulgaria.
The Echinops genus, part of the Asteraceae family, yields diverse bioactive compounds like thiophenes and terpenes. These natural products show significant therapeutic potential, warranting further research for medical applications.
Area of Science:
- Pharmacology and Botany
- Natural Product Chemistry
Background:
- Echinops, a genus in the Asteraceae family, comprises spiny perennials with significant pharmacological potential.
- Traditional and modern medicine recognize Echinops species for anti-inflammatory, antimalarial, antidiabetic, anticancer, and neuroprotective compounds.
Purpose of the Study:
- To systematically review and update recent phytochemicals and pharmacological properties of Echinops.
- To summarize the biological activities and therapeutic applications of compounds derived from the Echinops genus.
Main Methods:
- A systematic literature search was conducted across major databases (PubMed, Scopus, Science Direct, Web of Science, Google Scholar).
- Publications from 1990 to 2025 were included in the review.
Main Results:
- 134 studies met the inclusion criteria for the review.
- Thiophenes and terpenes are characteristic metabolites, alongside flavonoids and alkaloids, contributing to diverse bioactivities.
- Experimental data suggest multifunctional therapeutic potential, but clinical validation is limited.
Conclusions:
- Echinops represents a valuable source of structurally diverse metabolites with therapeutic relevance.
- Further pharmacological and toxicological investigations are essential to confirm efficacy and safety for medical use.
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