Biosynthesized Silver Nanoparticles and Their Antidiabetic Potential.

Area of Science:

• Nanotechnology and Materials Science
• Biochemistry and Molecular Biology
• Pharmacology and Therapeutics

Background:

• Diabetes mellitus is a metabolic disorder with persistent management challenges.
• Biosynthesized silver nanoparticles (AgNPs) are emerging as a novel therapeutic avenue.
• AgNPs demonstrate potential effects on glucose homeostasis-related enzymes and signaling pathways.

Purpose of the Study:

• To review the current research on the antidiabetic activity of biosynthesized AgNPs.
• To analyze in vitro and in vivo studies evaluating AgNPs for diabetes management.
• To present recent findings and future perspectives on AgNPs in diabetes treatment.

Main Methods:

• Narrative review of studies identified via PubMed search using "antidiabetic + activity + AgNPs".
• Focus on biosynthesized AgNPs from plant sources.
• Analysis of experimental approaches, plant sources, nanoparticle characteristics, concentrations, and outcomes.

Main Results:

• Green synthesis of AgNPs using plant bioactive compounds is an eco-friendly method.
• Plant extracts are the primary biomaterials for AgNP biosynthesis.
• In vitro studies often assess α-glucosidase/α-amylase inhibition; in vivo studies focus on blood glucose levels.

Conclusions:

• The antidiabetic potential of AgNPs is increasingly supported by scientific evidence.
• AgNPs offer a promising area for novel diabetes management strategies.
• Further research is needed to fully elucidate and harness the therapeutic benefits of AgNPs.