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Is Gestational Diabetes Mellitus Associated with Peripartum Infections?
Manal Massalha1,2, Rula Iskander1, Bibiana Chazan2,3
1Department of Obstetrics and Gynecology, Emek Medical Center, Afula 1834111, Israel.
Microorganisms
|September 27, 2025
Summary
Gestational diabetes mellitus (GDM) did not increase the risk of peripartum infections like chorioamnionitis or endometritis. This retrospective study found no significant difference in infection rates between women with GDM and matched controls.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Infectious Diseases in Pregnancy
Background:
- Gestational diabetes mellitus (GDM) is a common pregnancy complication.
- Peripartum infections, including chorioamnionitis and endometritis, pose risks to maternal health.
- The association between GDM and peripartum infection risk requires further clarification.
Purpose of the Study:
- To investigate the association between gestational diabetes mellitus (GDM) and the incidence of peripartum infections.
- To compare infection rates in women with GDM versus carefully matched controls without GDM.
Main Methods:
- Retrospective cohort study design.
- Inclusion of 1683 women with GDM and 1683 matched controls.
- Matching criteria included age, BMI, parity, and delivery methods.
- Primary outcome: rate of peripartum infections (chorioamnionitis and/or endometritis).
Main Results:
- No statistically significant difference in peripartum infection rates between GDM and control groups (1.5% vs. 0.8%, p=0.056).
- Multivariable logistic regression, controlling for confounders, showed no increased risk (OR 1.8, 95% CI 0.9-3.4).
- Common pathogens (E. coli, Group B Streptococcus) were similar in both groups.
Conclusions:
- Gestational diabetes mellitus is not associated with an increased risk of peripartum infections.
- Findings suggest GDM management does not need specific adjustments solely for peripartum infection prevention.
- Further research could explore specific subgroups or risk factors within GDM pregnancies.
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