Deep Eutectic Solvents in Capillary Electromigration Techniques-A Review of Recent Advancements

Area of Science:

• Analytical Chemistry
• Green Chemistry

Background:

• Deep eutectic solvents (DESs) are sustainable solvents with tunable properties like viscosity and polarity.
• Their low volatility and biodegradability make them attractive alternatives to traditional solvents.
• DESs are increasingly used in analytical extraction and separation processes.

Purpose of the Study:

• To critically evaluate the expanding role of DESs in capillary electromigration techniques.
• To summarize advancements in DES applications for capillary electrophoresis (CE) from 2019 to mid-2025.
• To delineate benefits, challenges, and future prospects of DES integration into CE workflows.

Main Methods:

• Systematic review of current literature on DESs in capillary electromigration.
• Analysis of diverse DES types used in electrophoretic separations.
• Investigation of mechanisms influencing chiral compound resolution using DESs.

Main Results:

• DESs are utilized as effective separation media and pseudostationary phases (PSPs) in capillary electromigration systems.
• Specific DES formulations demonstrate significant impact on chiral separation efficiency.
• Integration of DESs into CE offers enhanced analytical performance for various applications.

Conclusions:

• DESs present significant advantages for capillary electromigration techniques, including improved separation efficiency and sustainability.
• Challenges related to DES stability and reproducibility in CE require further investigation.
• Future research should focus on optimizing DES design and exploring novel applications in electromigration-based separations.