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Multi-Target Pharmacological Effects of Asiatic Acid: Advances in Structural Modification and Novel Drug Delivery
Xiaofan Dong1, Tianyi Wang1, Chenjia Gao1
1School of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
None:
Asiatic acid is an ursane-type pentacyclic triterpenoid compound extracted from the Umbelliferae plant Centella asiatica. Studies have shown that asiatic acid exhibits a wide range of pharmacological activities, including anti-tumor, anti-inflammatory, hypoglycemic, antimicrobial, neuroprotective, and wound healing effects. Asiatic acid is currently used in clinical settings in the form of tablets, capsules, and ointments, primarily for treating inflammation as well as burns, keloids, and other skin disorders. However, its poor water solubility, rapid metabolism, and low oral bioavailability have limited its clinical application for other diseases. Therefore, improving its water solubility and bioavailability is a prerequisite for addressing the limitations of asiatic acid in clinical use. This review summarizes the pharmacological mechanisms of action of asiatic acid and explains the reasons for its limited clinical application. This review describes methods to improve bioavailability through structural modifications of asiatic acid and the development of new formulations. It also focuses on enhancing the pharmacological effects of asiatic acid through the development and utilization of novel formulations such as nanoformulations and hydrogel formulations, providing a theoretical basis for the clinical translation of asiatic acid and the further research and development of asiatic acid-based drugs.
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