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Updated: Jan 16, 2026

Bioluminescent Bacterial Imaging In Vivo
Published on: November 4, 2012
Bacteria-Based Roles in Solid Tumors: Potential for Prevention and Treatment
Jianchang Huang1,2, Ailin Zhang1,2, Jialin Sun3
1School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Abstract:
Malignant tumors have become one of the most important diseases threatening human life and health, and the prevention and treatment of cancer have always been the direction of modern medicine's continuous exploration. According to modern medical research, a tumor microbial ecosystem exists in all human cancers. With the continuous deepening of research on the tumor microenvironment (TME), it has been discovered that some specific bacteria cause tumor production and development by damaging DNA, activating oncogenic signaling pathways, suppressing anti-tumor immunity, and producing pro-tumor metabolites. Certain bacteria associated with tumors can also serve as breakthroughs in the prevention and treatment of tumors. In this review, we present and summarize evidence from a large number of studies on the effects of oncobacteria on tumor prevention and treatment, and we further discuss the direction in which oncobacteria can be positively and effectively used in tumor therapy.
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