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Poloxamer-Based Biomaterial as a Pharmaceutical Strategy to Improve the Ivermectin Performance.
Belén Alejandra Mezzano1, Maria Soledad Bueno1, Valeria Cintia Fuertes2
1Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA) CONICET-UNC, Córdoba X5000HUA, Argentina.
Pharmaceutics
|September 27, 2025
Summary
Poloxamer 407 solid dispersions significantly enhance ivermectin
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Biomaterials Engineering
Background:
- Poloxamers are versatile biomaterials with potential in drug delivery.
- Enhancing biopharmaceutical properties is a key application for poloxamers.
- Ivermectin bioavailability can be limited by its poor aqueous solubility.
Purpose of the Study:
- To design and optimize solid dispersions of ivermectin using poloxamer 407.
- To investigate the impact of synthesis variables on poloxamer behavior and ivermectin properties.
- To evaluate the enhanced biopharmaceutical characteristics of the developed solid dispersions.
Main Methods:
- Fusion method employed for solid dispersion preparation.
- Systematic variation of synthesis parameters: polymer proportion, cooling gradient, and temperature.
- Comprehensive characterization including solubility, dissolution, and in vitro release studies.
Main Results:
- Confirmed compatibility between poloxamer 407 and ivermectin.
- Cooling rate significantly influenced poloxamer self-assembly and drug entrapment.
- Optimized 1:1 w/w ivermectin:poloxamer 407 solid dispersion showed a 1600-fold increase in aqueous solubility.
- Nanometric particle size and reduced crystallinity contributed to enhanced dissolution and drug release.
Conclusions:
- Poloxamer 407 solid dispersions offer a promising strategy for improving ivermectin bioavailability.
- The synthesis process, particularly cooling rate, is critical for optimizing solid dispersion performance.
- These formulations represent a viable alternative for enhancing the delivery of poorly soluble drugs like ivermectin.
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