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Hydrogels in Peri-Implant Regeneration: Strategies for Modulating Tissue Healing
Paula Buzo Frigério1, Nathália Dantas Duarte1, Mateus Meister Koury2
1Department of Diagnosis and Surgery, Aracatuba School of Dentistry (FOA-UNESP), São Paulo State University, Aracatuba 16015-050, Brazil.
Pharmaceutics
|September 27, 2025
Summary
Hydrogels show promise for bone tissue engineering around implants, offering biocompatibility and controlled release of agents. Further clinical studies are needed to confirm their effectiveness in peri-implant bone regeneration.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Hydrogels are advanced biomaterials for bone tissue engineering, particularly around implants.
- They offer biocompatibility, hydration, 3D defect filling, and extracellular matrix mimicry.
- Hydrogels support regeneration and deliver bioactive, immunomodulatory, and osteoinductive agents.
Purpose of the Study:
- To review recent advancements in hydrogel development and application for peri-implant bone defect repair.
- To summarize findings from preclinical and clinical studies on hydrogels in this context.
Main Methods:
- A narrative review methodology was employed.
- Literature search conducted across PubMed, Web of Science, and EBSCO databases.
- Studies published between 2010 and 2025 were included, totaling 14 preclinical and clinical investigations.
Main Results:
- Hydrogels demonstrate significant potential for peri-implant bone regeneration.
- Their biocompatibility and capacity for delivering therapeutic agents are key advantages.
- Preclinical data are highly encouraging, indicating efficacy in defect repair.
Conclusions:
- Hydrogels are promising for enhancing peri-implant bone regeneration.
- Clinical translation requires further investigation to validate efficacy and safety.
- Continued research is essential for successful clinical application of hydrogels in bone defect repair.
