Hydrogels in Peri-Implant Regeneration: Strategies for Modulating Tissue Healing

Background/Objectives: Hydrogels have emerged as strategic biomaterials in bone tissue engineering, especially in the peri-implant context, due to their high biocompatibility, water retention capacity, three-dimensional defect filling, and ability to mimic the extracellular matrix. These properties allow physical support for regeneration and the incorporation and controlled release of bioactive, immunomodulatory, and osteoinductive agents. Methods: This narrative review aimed to summarize recent advances in developing and applying hydrogels for the repair of peri-implant bone defects. The selection of studies was performed in PubMed, Web of Science, and EBSCO databases, covering the period from 2010 to 2025. Thus, 14 preclinical and clinical studies were included in this review. Results and Conclusions: Hydrogels show great potential for peri-implant bone regeneration due to their biocompatibility and ability to deliver bioactive agents. While preclinical results are promising, clinical validation remains limited. Further studies are needed to confirm their efficacy and ensure the safe translation of these findings into clinical practice.