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The Use of Nonhuman Primate Models for Advancing HIV PrEP.
Elena Bekerman1, Christian Callebaut1
1Gilead Sciences Inc., Foster City, CA 94404, USA.
Viruses
|September 27, 2025
Summary
Nonhuman primate models are crucial for advancing HIV pre-exposure prophylaxis (PrEP) research. These models accurately predict the clinical efficacy of various PrEP strategies, aiding in the development of new HIV prevention tools.
Area of Science:
- Virology
- Immunology
- Pharmacology
Background:
- Pre-exposure prophylaxis (PrEP) is vital for global HIV/AIDS control, but requires ongoing innovation for better adherence and access.
- Nonhuman primate (NHP) models infected with simian immunodeficiency virus (SIV) are instrumental in HIV PrEP research.
Purpose of the Study:
- To review the utility of NHP models in evaluating diverse HIV PrEP strategies.
- To assess the predictive value of NHP models for clinical PrEP efficacy.
Main Methods:
- Examination of NHP models for oral, injectable, implantable, and topical PrEP formulations.
- Analysis of challenge models simulating human HIV transmission routes.
- Review of pharmacokinetic and safety data from NHP studies.
Main Results:
- NHP models have demonstrated high predictive power for clinical HIV PrEP efficacy.
- Successful translation of NHP findings for tenofovir-based regimens, cabotegravir, and lenacapavir into clinical settings.
- NHP studies inform the design of next-generation HIV prevention tools.
Conclusions:
- NHP models are indispensable for evaluating HIV PrEP efficacy, pharmacokinetics, and safety.
- Species-specific pharmacologic considerations are important in NHP PrEP research.
- NHP data significantly contributes to developing novel HIV prevention strategies and ending the HIV epidemic.
