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Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
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  11. Effects Of Intra-uterine Ceftiofur On The Equine Uterine Microbiome.
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  11. Effects Of Intra-uterine Ceftiofur On The Equine Uterine Microbiome.

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Effects of Intra-uterine Ceftiofur on the Equine Uterine Microbiome.

Kalie F Beckers1, Chin-Chi Liu1, Viviane C L Gomes2

  • 1Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.

Veterinary Sciences
|September 27, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Intrauterine ceftiofur infusion did not acutely alter the equine uterine microbiome in mares during estrus. Further studies are needed to assess potential long-term impacts on the equine endometritis microbial community.

Keywords:
antibioticsequinepregnancy microbiome

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Area of Science:

  • Veterinary Medicine
  • Microbiology
  • Equine Science

Background:

  • Antimicrobial therapy is crucial for treating equine reproductive diseases like endometritis.
  • Ceftiofur, a third-generation cephalosporin, is frequently used intrauterinely (IU) in mares.
  • Its empirical use raises questions about its impact on the healthy uterine microbiome.

Purpose of the Study:

  • To investigate the acute effects of IU ceftiofur on the estrual uterine microbiome in mares.
  • To test the hypothesis that ceftiofur disrupts the resident microbial community in healthy equine uteri.

Main Methods:

  • Characterization of the estrual uterine microbiome in eight mares before and after IU ceftiofur or saline.
  • Utilized double-guarded swabs for endometrial sampling.
  • Employed 16S rRNA gene sequencing (V4 region) via Illumina Miseq for bacterial community analysis.

    • Main Results:

    • No significant difference in uterine microbial composition was observed between sham and ceftiofur-treated groups based on beta diversity.
    • A statistically significant decrease in the abundance of Christensenellaceae_R-7_group was noted post-ceftiofur treatment (p=0.0428).

    Conclusions:

    • Acute, three-day IU ceftiofur treatment did not significantly alter the equine uterine microbiome during estrus.
    • The findings suggest ceftiofur should be used judiciously in mares.
    • Long-term effects on the uterine microbiome warrant further investigation with later sampling times.