The Hemoglobin, Albumin, Lymphocyte, and Platelet Score as a Prognostic Indicator for Dogs with Congestive Heart

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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
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In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

Published on: February 16, 2016

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Jayeon Park1, Yeon Chae1, Sungjae Lee1

  • 1Laboratory of Veterinary Internal Medicine, College of Veterinary Medicine, Chungbuk National University, Cheongju 28644, Republic of Korea.

Veterinary Sciences
|September 27, 2025
PubMed

Insights

The HALP score, a novel marker, effectively predicts short-term mortality in dogs with congestive heart failure (CHF) due to myxomatous mitral valve disease (MMVD). Higher HALP scores indicate better survival, offering a valuable prognostic tool for canine heart disease.

Area of Science:

  • Veterinary Cardiology
  • Canine Internal Medicine
  • Biomarker Discovery

Background:

  • Prognostic indicators for congestive heart failure (CHF) in dogs with myxomatous mitral valve disease (MMVD) are limited.
  • The hemoglobin, albumin, lymphocyte, and platelet (HALP) score is a human prognostic marker not yet evaluated in veterinary medicine.

Purpose of the Study:

  • To evaluate the utility of the HALP score for predicting short-term mortality in dogs with CHF secondary to MMVD.
  • To determine if the HALP score can serve as a novel prognostic indicator in this canine population.

Main Methods:

  • Retrospective study of 54 small-breed dogs with CHF due to MMVD.
  • Calculation of the HALP score: (hemoglobin × albumin × lymphocytes) / platelets.
  • Assessment of mortality at six, nine months, and one year using ROC and Kaplan-Meier analyses.

Main Results:

  • The HALP score was significantly higher in survivor groups.
  • ROC analysis demonstrated good predictive accuracy for six- and nine-month mortality (AUC > 0.7).
  • A HALP score cut-off of 11.13 predicted six-month mortality with 44.44% sensitivity and 94.44% specificity.

Conclusions:

  • The HALP score is a valuable and novel prognostic indicator for short-term mortality in dogs with CHF due to MMVD.
  • Higher HALP scores are associated with significantly longer survival times in affected dogs.

Keywords:
CHFHALP scoreMMVDdogprognosisshort-term mortality

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