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Hypertrophic cardiomyopathy in Nigeria: protocol for a systematic review

Okechukwu S Ogah1,2, Franklin Obiekwe3, Oluwadamilotun Oguntuga3

  • 1Cardiology Unit, Department of Medicine, University of Ibadan, Ibadan, Oyo state, Nigeria. osogah56156@gmail.com.

BMC Cardiovascular Disorders
|September 27, 2025
PubMed

Insights

This systematic review examines hypertrophic cardiomyopathy (HCM) in Nigeria, a leading cause of sudden cardiac death. It aims to consolidate existing data on HCM prevalence and clinical characteristics within the country.

Area of Science:

  • Cardiology
  • Genetics
  • Public Health

Background:

  • Hypertrophic cardiomyopathy (HCM) is a significant global cause of sudden cardiac death, often inherited in an autosomal dominant pattern.
  • While advancements have improved HCM outcomes, data from Nigeria are scarce, with most research concentrated in single centers.
  • This systematic review addresses the limited understanding of HCM in Nigeria.

Purpose of the Study:

  • To conduct the first systematic review on the prevalence and clinical profile of hypertrophic cardiomyopathy in Nigeria.
  • To identify research gaps and inform future studies on HCM in the Nigerian population.

Main Methods:

  • A comprehensive search of multiple databases (PubMed/Medline, EMBASE, Web of Science, Google Scholar, African Index Medicus, African Journal Online) will be performed.
  • Articles published in English from 1960 to 2024, including case reports, case control, cross-sectional, and cohort studies, will be analyzed.
  • Three independent reviewers will manage article selection and data extraction.

Main Results:

  • The review will report on the prevalence of HCM in Nigeria.
  • It will detail the clinical profile and characteristics of HCM patients in Nigeria.

Conclusions:

  • This study represents the first systematic review focusing on HCM prevalence and clinical presentation in Nigeria.
  • The findings are expected to highlight areas for future research and improve understanding of HCM within the Nigerian context.
Abstract

Keywords:
CardiomyopathyEchocardiographyHypertrophic cardiomyopathyPrevalence

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