TERT promoter C250T mutation in a recurrent cervical chordoid meningioma: a unique case report

Chordoid meningioma (CM) is an uncommon histological variant of meningioma, typically found intracranially. Intraspinal occurrences, particularly in the cervical region, are exceedingly rare. We report a unique case of a 73-year-old male with cervical spinal CM who experienced tumor recurrence two years after gross total resection (GTR). Histopathological analysis confirmed the recurrence as anaplastic meningioma with telomerase reverse transcriptase (TERT) promoter C250T mutation, CNS WHO Grade 3-marking the first documented association of this mutation with spinal CM. This case underscores the diagnostic, molecular, and prognostic complexities of spinal CM and highlights the critical role of TERT promoter mutation in tumor behavior and classification.