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A recurrent OKC infected with actinomyces.

Yuxin Ma1, Lin Yang2, Bao Zhong3

  • 1Department of Medical imaging, Central Laboratory of Jinan Stomatological Hospital, Jinan Key Laboratory of Oral Tissue Regeneration, Jinan, Shandong, China.

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|September 27, 2025
PubMed
Summary
This summary is machine-generated.

Recurrent odontogenic keratocyst (OKC) can lead to actinomycotic osteomyelitis. Surgical resection and antibiotic treatment are effective for this rare complication, improving patient outcomes.

Keywords:
Actinomycetic osteomyelitisCone-beam computed tomography CBCTMandibularOdontogenic keratocystic OKCPathological

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Area of Science:

  • Oral and Maxillofacial Surgery
  • Pathology
  • Infectious Diseases

Background:

  • Recurrence of mandibular odontogenic keratocyst (OKC) with secondary actinomycotic osteomyelitis is a rare clinical challenge.
  • This case highlights the diagnostic and therapeutic difficulties associated with this rare condition.

Purpose of the Study:

  • To present a case of recurrent OKC with secondary actinomycotic osteomyelitis.
  • To combine imaging, pathological data, and literature review for clinical management guidance.

Main Methods:

  • A case study approach was used.
  • Imaging and pathological data were analyzed.
  • Relevant literature was reviewed.

Main Results:

  • A 21-year-old female with a history of polycystic OKC presented with recurrent symptoms.
  • Pathological examination confirmed OKC and chronic actinomycotic osteomyelitis.
  • Surgical resection, curettage, and postoperative clindamycin treatment resulted in a good prognosis.

Conclusions:

  • Odontogenic keratocyst (OKC) recurrence can compromise the oral mucosal barrier, potentially causing actinomycotic osteomyelitis.
  • Accurate diagnosis relies heavily on pathological examination.
  • Surgical resection combined with postoperative antibiotics is an effective treatment strategy for secondary OKC and actinomycotic osteomyelitis.