Primary cardiac endosarcoma: a case report.

Area of Science:

• Cardiovascular Oncology
• Rare Cancers
• Genomic Medicine

Background:

• Primary cardiac intimal sarcoma is an exceptionally rare and aggressive malignancy with a median survival under 1 year.
• MDM2 amplification is a rare genetic alteration found in some cardiac sarcomas.
• Limited treatment options contribute to the poor prognosis of this disease.

Purpose of the Study:

• To report a rare case of primary cardiac intimal sarcoma with MDM2 amplification.
• To describe the multimodal treatment approach and its impact on patient survival.
• To offer insights into managing this highly lethal condition.

Main Methods:

• A 48-year-old woman presented with symptoms of a large left atrial mass.
• Diagnosis of intimal sarcoma with MDM2 amplification was confirmed via histopathology and genetic analysis.
• Treatment involved surgical resection, followed by sequential therapies including liposomal doxorubicin, anlotinib, and combination chemotherapy.

Main Results:

• The patient underwent successful surgical resection of the cardiac tumor.
• Despite initial recurrence, sequential therapies led to partial tumor regression and clinical stability.
• The patient achieved survival exceeding 1 year post-diagnosis, with ongoing treatment.

Conclusions:

• Combining surgery, chemotherapy, and targeted therapy may prolong survival in primary cardiac intimal sarcoma.
• Anlotinib-based therapy shows potential for managing MDM2-amplified cardiac intimal sarcoma.
• This case underscores the need for further clinical investigation into novel therapeutic strategies.