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Related Concept Videos

Preparation of Samples for Electron Microscopy01:20

Preparation of Samples for Electron Microscopy

To be visualized by an electron microscope, either transmission or scanning, biological samples need to be fixed (stabilized) so the electron beam does not destroy them and dried thoroughly (desiccated/dehydrated) so the vacuum does not affect them. Fixation needs to be done as quickly as possible because the sample properties will start changing as soon as it is removed from its natural environment. For example, in a tissue sample, the oxygen levels begin decreasing, causing an altered...

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Needle-free, Liquid Metal-embedded Electrospray Deposition System for Controlled Microdroplet Printing.

Chaeyeong Kang1, Seokbeom Roh2,3, Hyunjun Park4

  • 1Department of MetaBioHealth, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|September 27, 2025
PubMed
Summary

A novel liquid metal-embedded electrospray deposition (LM-ESD) system simplifies fabrication and enhances efficiency for precise liquid manipulation. This technology eliminates external ionization hardware, improving reproducibility for various applications.

Keywords:
droplet array printingelectrospray depositionliquid metal integrationmicrodroplet generationpdms‐based microfluidics

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Area of Science:

  • Microfluidics
  • Materials Science
  • Biomedical Engineering

Background:

  • Conventional electrospray systems are vital in biomedical, pharmaceutical, and materials science but suffer from complex designs, external ionization needs, clogging, and poor reproducibility.
  • Existing technologies often require additional hardware, increasing system complexity and limiting efficiency.

Purpose of the Study:

  • To introduce a simplified and more efficient electrospray deposition system.
  • To eliminate the need for external ionization components in electrospray setups.
  • To enhance the precision and reproducibility of droplet array formation.

Main Methods:

  • Development of a liquid metal-embedded electrospray deposition (LM-ESD) system integrated into a microfluidic chip.
  • Leveraging the intrinsic electric field of the microfluidic chip for ionization.
  • Validation of spray performance using advanced microscopy (fluorescence, SEM, AFM, KPFM) and Raman spectroscopy.

Main Results:

  • The LM-ESD system successfully eliminates the requirement for external ionization hardware.
  • Fabrication processes are simplified, and design complexity is reduced.
  • Uniform droplet arrays with high reproducibility were confirmed through multiple validation techniques.

Conclusions:

  • The developed LM-ESD system offers a simplified, efficient, and reproducible alternative to conventional electrospray technologies.
  • This versatile system demonstrates significant potential for precision printing, thin-film deposition, and high-throughput analysis.
  • The intrinsic electric field utilization paves the way for more integrated and robust microfluidic electrospray applications.