Examining Atopic Dermatitis Through the One Health Concept Lens

Area of Science:

• Integrative medicine
• Environmental health
• Dermatology

Background:

• Atopic dermatitis (AD) is a complex, chronic skin condition.
• The One Health framework integrates human, animal, and environmental health to address global challenges.
• Urbanization, climate change, and pollution are increasingly linked to allergic diseases.

Purpose of the Study:

• To explore the application of the One Health framework to atopic dermatitis (AD).
• To identify etiological factors of AD influenced by environmental and lifestyle changes.
• To propose innovative, interdisciplinary prevention and management strategies for AD.

Main Methods:

• Literature review and synthesis of One Health principles applied to AD.
• Analysis of etiological factors including urbanization, climate change, and pollution.
• Examination of human-dog microbiota sharing and the "old farm effect" for protective factors.
• Web data mining to correlate public interest with environmental factors.

Main Results:

• Rural environments and traditional lifestyles show protective effects against AD, evidenced by human-dog microbiota studies and the "old farm effect".
• Climate change (e.g., increased CO2, extreme weather) exacerbates AD symptoms and allergenicity.
• Environmental pollutants (e.g., black carbon) negatively impact skin microbiome and immune barriers, increasing AD prevalence.
• Web data mining reveals correlations between public interest in AD and environmental factors, highlighting awareness gaps.

Conclusions:

• An integrated One Health approach is crucial for understanding and managing AD.
• Reversing trends of urbanization and environmental degradation, and promoting lifestyle diversity, are key for AD prevention.
• Innovative cross-species solutions, including veterinary interventions and digital tools, offer promising avenues for personalized and sustainable AD care.